role of vascular endothelial growth factor [VEGF] in development of diabetic micro vascular complications

ABSTRACT

The aim of this study to determine serum level of VEGF in patients with Diabetic Micro vascular and macrovascular complication as Diabetic Nephropathy, retinopathy and cardiovascular insufficiency mainly acute myocardial infarction. Fifty individuals were investigated. 10 apparently healthy persons [4 females and 6 males] as control group, 20 maturity onsets diabetic patients [non-insulin dependent] with diabetic nephropathy [8 females and 12 males], 10 maturity onset diabetic patients [non-insulin dependant] with diabetic retinopathy [4 female and 6 males] and 10 maturity onset diabetic patients [non-insulin dependant] with acute myocardial infarction [4 female and 6 male]. Serum level of VEGF was measured in those patients and correlated with different clinical and laboratory investigations. Serum level of VEGF was significantly high in diabetic patient with micro-vascular complication "629.75 +/- 317.07' compared with healthy control 139.75 +/- 12.97". Serum level of VEGF was significantly high in patients with Diabetic riephropathy "553 +/- 232.03", compared with healthy control "139.4 +/- 12.97". Serum level of VEGF was significantly high in patients with diabetic retinopathy "507 +/- 327" compared with healthy control "139.4 +/- 12.97". Serum level of VEGF was significantly high in diabetic patients with acute myocardial infaction "807 +/- 316.01" compared with healthy control "139.4 +/- 12.97". There was significant positive correlation between serum VEGF, serum creatinine and microablumjnuria. These Data suggest that VEGF plays control role in mediating micro vascular pathology in Diabetes. VEGF may be one of the markers and risk factors for micro-albuminuria and incipient diabetic Nephropathy. There was significant correlation between VEGF level and recent acute myocardial infarction, which may postulate that VEGF serve a salutary role in hypoxic myocardial tissue of coronary artery disease by promoting development of collateral circulation