Ciprofloxacin ear drop for active chronic suppurative otitis media; It is safe and effective

ABSTRACT

This study was designed to show the efficacy of Ciprofloxacin ear drop in 30 patints [40 ears] with active chronic suppurative otitis media [CSOM]. It was performed at Al-Rasheed Military Hospital, Baghdad, Iraq [between may-2001 and jun-2002]. The study was a pilot, observational screening study. Measurements performed included clinical assessment [healing rate and adverse effects] and culture and sensitivity of ear discharge. Results have shown that ciprofloxacin ear-drop was found effective in reducing the otorrhea and making the discharge aseptic. This effect seems to be dose dependant since it is more pronounced and rapid at the higher dose. The success rates after 8 days were 93.3% and 60% for 0.5% and 0.25% of Ciprofloxacin concentration respectively. No important adverse effects were reported during the course of treatment. In addition there were no signe of local intolerance or ototoxicity during the period of drug administration. Ciprofloxacin ear-drop appeared to be safe and effective in treating active CSOM