Hyperhomocysteinemia as an independent risk factor for coronary artery disease

ABSTRACT

We examined whether hyperhomocysteinemia is an independent risk factor for the development of coronary artery disease [CAD] in randomly selected 25 male patients who have angiographically proved CAD and without any of classical cardiovascular risk factors. And 20 male healthy volunteers are enrolled in this study. The outcome measures include; coronary angiography, ECG, SBp, DBp, FBS, Fasting plasma total Homocysteine [tHcy], Lipid profile, and anthropometric measures. The results showed that all patients and volunteers were below 45 years age, no one of the patients had obesity, hypertension, diabetes mellitus, dyslipidemia or smoking habit. The results: there were no significant difference between patients and controls regarding age, BMI, WHR, SBp, DBp, FBS, and Lipid profile [P>0.05]. While there were a significant higher levels in fasting plasma tHcy in patients compared to that of controls [P< 0.05]. Our results indicate that fasting plasma tHcy levels may act as an independent risk factor for development of CAD, and this result may open anew line of treatment of cardiovascular disease by using drugs that affect the levels of plasma homocystein