Complete androgen blockade in advanced prostate cancer: a clinical experience

ABSTRACT

To evaluate the clinical and biochemical outcome of patients with advanced prostate cancer treated by complete androgen blockage [CAB]. A total number of thirty patients with histologically confirmed advance prostate cancer and serum PSA level of more than 30ng/ml were subjected to bilateral subcapsular orchidectomy, supplemented with oral antiandrogens. These patients were followed for a period of two years by recording their symptoms and serum PSA level at twelve weeks intervals. Only 16[53.33%] patients complied with the protocol of the study and observed two years followup. 12[75%] patients showed complete response to CAB while 4[25%] patients showed rising PSA levels and became symptomatic after one year of treatment. CAB is still the treatment of choice for patients with advanced prostate cancer