Serum P.S.A level in clinical prostatitis

ABSTRACT

This work is an attempt to find out a practically applicable correlation between the changes of serum [P.S.A] in patients with symptomatic, clinical Prostatitis [acute and chronic] and the natural history of the disease. A total of 45 cases, age ranges 22-47 years and U/S prostate volume ranges 18-30 ml, 8 cases of acute prostatitis [A.P], 14 cases chronic bacterial prostatitis [C.B.P], and 23cases of chronic non-bacterial prostatitis [N.B.P]. Medical therapy for 6 weeks to all patients, and Serum [P.S.A] was measured at presentation then 3 and 6 weeks after starting medical therapy, and the degree of serum [P.S.A] elevation was assigned as mild [>the age-specific range but < 4 ng/ml], moderate [from 4 to 10 ng/ml] and significant [>10 ng/ml].All patients have attended follow-up for 9-12 months to evaluate for clinical relapse. Using the Age-Specific reference range; at presentation Serum [P.S.A] was elevated in 25 patients [55.6 percent of the total], it includes all cases of [A.P], 8 out of 14 cases of [C.B.P] and 9 out of 23 cases of [N.B.P]. The elevation was mild in 13 cases, moderate in 8 cases and significant in 4 cases. After 3-6 weeks of medical [antibiotics] treatment, serum [P.S.A] has decreased to the normal range in 21 out of the 25 cases [84 percent] and it was associated with significant clinical improvement during 9-12 months. Although clinical improvement and no growth cultures of the Expressed Prostatic Secretion [E.P.S] are achieved within 1-2 weeks of treatment, substantial reduction or normalization of [P.S.A] isn't achieved before 3-6 weeks of therapy; and it may be a better indicator regarding control of the inflammatory process and a hallmark of infrequent clinical relapse