Complicated Crohn 's disease

ABSTRACT

Crohn's disease is a debilitating, Chronic inflammatory disease that is neither medically or surgically Curable. [1] Approximately 60-70 percent of all patients with Crohn's disease will eventually need to undergo surgery for the disease. [2] In 2040 percent of patients, the disease is complicated by the development of a Fistula or a deep penetrating abscess. [3] Several studies with INFLIXIMAB have clinically demonstrated that the antitumour necrosis factor-alpha therapy rapidly reduces signs and symptoms in patients with moderate to-severe Crohn's disease. [4] The objective: To increase awareness by this uncommon disease process and through light on a newly therapeutic agent that can reduce and maintain remission in a patient population in this retrospective study, we analyze the clinical records of 17 patients [13 males, 4 Females] as regard presentation, history, Clinical examination, investigation and treatment regimens and operative details. Four patients presented as acute appendicitis, 2 patients with terminal ileal perferation, 2 patients with abdominal masses, 3 patients with acute abdowen, 2 patients with peria pendicular abscess, 2 patients with intestiol abslructionand 2 cases with malnutrition. In 4 cases inflexemab was added to the treatment regimm leading to rapid cure Crohn's disease, though considered uncommon, can account for 1060 percent afacute abdominal disorders. Thus every physician or surgeon in deal with acute abomen should bear in mind a Crohn's possibility Infliximab, a therapeutic agent that can induce and maintain remission, while promoting the restoration of intestinal mucosa, would prove to be most beneficial in such a patient population