Role of interferon-alpha, interleukin-1 beta and T cell activation in aplastic anemia pathogenesis

ABSTRACT

The present work was performed to clarify the role of stimulatory cytokine as IL-1 beta and inhibitory cytokine as IFN-gamma and T cell activation evidenced by CD25 expression in the pathogenesis of aplastic anemia. Twenty-eight newly diagnosed aplastic anemia patients and 15 age and sex matched healthy controls were included in this study. An estimation of IL-1 beta, IFN-gamma and the percentage of CD25 expression was done to all patients and controls. IFN-gamma was significantly higher in AA patients as compared with the age matched controls. IL-1 beta was significantly lower in AA patients as compared with the controls. The percentage of CD25 expression was significantly higher in AA patients as compared with the controls. There was a highly positive significant correlation between IFN-gamma and leucocytopenia. There was a negative significant correlation between IL-1 beta and each of age and leucocytopenia. There was a highly positive correlation between CD25 expression and Hb level of the patients