Study of the interaction between insulin, insulin-like growth factor-1 [IGF-1] and sympathetic nervous system in patients with hepatorenal syndrome
Medical Journal of Cairo University [The]. 2004; 72 (4): 731-738
em Inglês
| IMEMR
| ID: emr-67626
ABSTRACT
The current study was conducted to understand the interactions between the sympathetic nervous system [SNS], insulin and IGF-1 in cirrhotic patients with renal impairment. This study included 42 patients with cirrhosis [14 cases without ascites, 16 with ascites and 12 with HRS] and 13 healthy subjects as a control group. Enzyme immunoassay technique was used for measurement of serum insulin, serum IGF-1 plasma noradrenaline and plasma neuropeptide Y [NPY]. The results suggested that low circulating IGF-1 might contribute to renal functional impairment in cirrhotic patients. Further studies are necessary to evaluate whether IGF-1 can become a useful therapeutic agent in patients with liver cirrhosis and HRS. Progressive impairment in systemic hemodynamics in cirrhotic patients might underlie a detective sympathetic response which deserves intensive research studies
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Neuropeptídeo Y
/
Fator de Crescimento Insulin-Like I
/
Norepinefrina
/
Insulina
/
Testes de Função Renal
/
Cirrose Hepática
/
Testes de Função Hepática
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Cairo Univ.
Ano de publicação:
2004
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