Thalassemia intermedia and prevalence of anti-hepatitis C antibodies and other hepatitis markers

ABSTRACT

This study aimed to find out the prevalence of anti-hepatitis C virus antibodies [anti-HCVAb] and hepatitis B virus [HBV] markers in children with TI and their relation with age, sex, the number of blood units transfused and ferritin level in addition to determining the infection's effects or liver functions. Twenty-eight patients [13 males and 15 females] suffering from TI with a mean age 11.7 +/- 4.9 years were compared with 15 healthy children of the same age and sex. Complete blood count, hemoglobin electrophoresis, liver and kidney functions tests and ferritin level were done in addition to assessment of anti-hepatitis C antibodies [anti-HCVAb], hepatitis B surface antibodies [anti-HBcAb] by ELISA technique. In conclusion, HCV infection might be the cause of morbidity among the occasionally blood transfused thalassemia inter- media patients, even with their low rate of transfusion and even after the introduction of procedures to screen blood products for HCV. Egyptian blood donors should be effectively screened for anti-HCV and individuals who have a history of drug abuse should be deferred from donating the blood. This and stringent infection-control measures are necessary steps to limit the spread of HCV, HBV and perhaps other viruses to patients