Circulating soluble Fas and Fas antigen tissue expression in human bladder cancer

ABSTRACT

This study was performed to determine the role of sFas and Fas expression in human bladder cancer. The percussion of schistosomiasis association and correlations between various parameters and tumor progression were evaluated as well. Fifty patients [24 with chronic cystitis and 26 with bladder cancer [20 with transitional cell carcinoma and 6 with squamous cell carcinoma]] were included in this study and fifteen individuals served as normal controls. SFas level in sera was estimated using enzyme linked immunosorbent assay. Fas expression in bladder tissue was immunohistochemically determined. SFas level and% of Fas expression in chronic cystitis and bladder cancer patients were significantly higher than normal controls. Moreover, a significant increase in sFas level and% of Fas expression was detected in chronic cystitis associated with schistosomiasis compared to chronic nonspecific cystitis. SFas level was significantly increased with tumor progression in the invasive group compared to the noninvasive group; whereas,% of Fas expression was comparable in both groups. Moreover, the number of Fas positive cases was significantly high in invasive than noninvasive