Combination of fluoxetine and nortriptyline in the treatment of obsessive compulsive disorders
MJIH-Medical Journal of the Iranian Hospital. 2004; 6 (2): 16-20
em Inglês
| IMEMR
| ID: emr-67782
ABSTRACT
There is growing interest in investigating noradrenergic functions in Obsessive Compulsive Disorder [OCD] because some antidepressants with strong effects of serotonin reuptake inhibition fail to relieve obsessive-compulsive symptoms. We undertook a trial to investigate whether the combination of fluoxetine with nortriptyline is more effective than fluoxetine alone. Thirty nine patients who met the DSM-IV criterias for OCD were included in the study. Patients were allocated in a random fashion, 19 patients to fluoxetine 40mg/day plus nortriptyline 40mg/day and 20 patients to fluoxetine 40mg/day plus placebo. Although both protocols significantly decreased the scores of the Yale-Brown obsessive-compulsive scale over the trial period, the combination of fluoxetine and nortriptyline showed a significant superiority over fluoxetine alone in the treatment of OCD. As this study indicates, a rapid onset of action is one of the advantages of this combination. This study supports further investigation of the noradrenergic-serotoninergic hypothesis in OCD
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Fluoxetina
/
Terapia Combinada
/
Quimioterapia Combinada
/
Nortriptilina
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Iran. Hosp.
Ano de publicação:
2004
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