Oxidative protein damage in Postmenopausal women receiving hormonal replacement therapy

ABSTRACT

To study the effect of hormone replacement therapy [HRT] on the oxidative protein damage [OPD] by investigating protein carbonyl [PCO], nitrotyrosine [NT] and total thiol [T-SH] levels. Department of obstetrics and gynecology, faculty of medicine, Al-Azhar University prospective study. Forty eight postmenopausal women.who received HRT, were followed up for 6 months. Baseline values of OPD [PCO, NT, T-SH], plasma lipids [total triglycerides and cholesterol], lipoprotein, apolipoprotein, and hemostatic factors [fibrinogen, Antithrombin III, protein C]. were measured. Measurement was done at 6 of the follow-up study. HRT had a significant effects on serum levels PCO, NT, and T-SH. PCO Baseline vs After 6 months significant [p<0.0001]. NT Baseline vs 6 months significant [p<0.001]. T-SH Baseline vs after 6 months significant [p<0.0001]. Hormonal replacement therapy can induce favorable changes in the plasma lipoprotein cholesterol pattern and measures of oxidative protein damage