Immunohistolocalization of c-erbB-2 protein: a proliferative marker in benign prostatic hyperplasia

ABSTRACT

To examine possible role of c-erbB-2 in the development of benign prostatic hyperplasia. Design: A retrospective study of 25 patients suffering from benign prostatic hyperplasia. Setting: BMSI, Jinnah Postgraduate Medical Centre, Karachi. Subjects: Twenty five patients between the ages of 51-80 years were selected for the period of 2001 suffering from benign prostatic hyperplasia. Results of study show that overall frequency of c-erbB-2 expression was not found. Maximum numbers of BPH among total cases were in age group 61-70 years i.e 13 tumours [52% of total cases]. Results of current study and work of previous researchers indicate a lot of controversy over c-erbB-2 immunostaining in benign prostatic hyperplasia. Further study is required to elucidate the precise role played by this protein marker in the benign growth of prostatic tissue