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Promising early results for keloid treatment with intralesional colchiciae a clinical and histopathological study
Scientific Medical Journal. 2004; 16 (2): 1-11
em Inglês | IMEMR | ID: emr-68967
ABSTRACT
In a clinical trial, 14 cases with keloids were treated by local infiltration of colchicines. The results were evaluated objectively and subjectively. Lesional biopsy was obtained before and after treatment and examined by light microscopy. Marked reduction of the size of the lesions and decrease of such complaints as itching and erythema were noted. Favorable results were obtained according to the patients in 83.4% and according to the opinion of the medical examiner in 91.7% of cases. Systemic complications of colchicines absorption, i.e. nausea, did not occur in any patient. Histopathologic examination of the lesions after colchicines infiltration reveled marked reduction in the density of collagen bundles which are widely dispersed throughout the dermis. Intralesional infiltration of colchicines is safe and effective treatment of keloids
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Injeções Intralesionais / Colchicina / Estudos Retrospectivos / Resultado do Tratamento / Histologia Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Sci. Med. J. Ano de publicação: 2004

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Injeções Intralesionais / Colchicina / Estudos Retrospectivos / Resultado do Tratamento / Histologia Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Sci. Med. J. Ano de publicação: 2004