Role of plasma vascular endothelial growth factor [VEGF] in type-2 diabetes mellitus, with and without nephropathy, and its relation to glycemic control

ABSTRACT

To determine the plasma concentration of vascular endothelial growth factor [VEGF] and to investigate its possible role in diabetic nephropathy. A randomized, group comparative, and crossectional study. A total of 50 type-2 diabetic patients, 30 of them were complicated by nepthropathy, and other 20 diabetic patients without nephropathy, and 20-matched of non-diabetic control subjects. Suiz Canal University Hospital. Plasma concentration ol' VEGF, HbAlc, plasma glucose, albumin excretion rate [AER], and serum creatinine. The type-2 diabetic patients with and without nephropathy had plasma level of VEGF significantly higher than that of controls. Diabetic patients with nephropathy had significantly higher plasma level of VEGF than that of diabetics without nephropathy. Significant positive correlations exist between the plasma concentration of VEGF and fasting, 2-h postprandial blood glucose, glycosylated hemoglobin [HBAIc], and AER. VEGF may play an important role in mediating diabetic nephropathy