Evaluation of platelet activation in platelet concentrates during storage in the quality control laboratory of Iranian blood transfusion organization in 2004

ABSTRACT

Conditions for preparation and storage of platelets for transfusion purposes may lead to platelet activation which in turn contributes to decreased ability of stored platelets to function and to survive in after transfusion as compared with freshly prepared platelets. We investigated platelet membrane expression of CD62P, CD63 in platelet stored for up to 3 days under standard blood banking conditions. Twenty-four platelet units prepared by platelet-rich-plasma and platelet concentrates were evaluated during storage for markers CD2P, CD63 and pH. During storage for up to 3 days platelet units displayed no significant pH [p>0.05]. During storage for up to 3 days [days 1 and 3] platelet units were significant in the CD62P and CD63 expressions as compared with day 0 [p<0.05]. Storage of platelet concentrates causes activated platelets. Moreover, these markers [CD2P and CD63] can act as useful in vitro means in the quality control of platelet components