Thermal decomposition of tetracycline and cephalosporins metal complexes
Bulletin of Pharmaceutical Sciences-Assiut University. 2005; 28 (2): 269-276
em Inglês
| IMEMR
| ID: emr-70246
ABSTRACT
Thermal behaviour of tetracycline hydrochloride, oxytetracycline dihydrate, Co [II] and Ni [II] complexes of tetracycline and Zn [II] complexes of some cephalosporin antibiotics, namely cephalexin, cephapirin, cefuroxime, and ceftazidime was studied using thermogravimetric analysis [TG]. The TG curves exhibit several thermal events indicating that the thermal decomposition of these compounds are not simple. The kinetic parameters for steps appropriate for kinetic analysis were evaluated making use of the Coats-Redfern equation. During the thermal decomposition of tetracycline hydrochloride anhydro tetracycline was proposed to be formed as an intermediate due to the elimination of water
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Termogravimetria
/
Zinco
/
Microscopia Eletrônica de Varredura
/
Cefalosporinas
/
Combinação de Medicamentos
Idioma:
Inglês
Revista:
Bull. Pharm. Sci.-Assiut Univ.
Ano de publicação:
2005
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