Experimental study of biochemical effects of insecticides in albino rats

ABSTRACT

To detect the acute toxicity of some insecticide rats were divided into ten treatments each one contained six rats. These rats administered a single oral dose of 1/10 LD[50], 1/4 LD[50] and the LD[50] of primiphos-methyl, Chlorpyriphos-methyl and fenitrothion. After 24 hr treated rats were sacrificed. The activity of some biochemical parameters glutamic oxaloacetic transaminase [GOT], glutamic pyruvic transaminase [GPT], alkaline phosphatase [Alk. Ph.], creatinine, urea, total protein and total cholesterol] were detected in blood serum. The results indicated that all treatments caused significant increase in the activity of GOT, GPT and [Alk. Ph.], as well as the level of creatinine, urea and total cholesterol as compared by control ones. While the results indicated that 1/4 LD[50] and 1/10 LD[50] of the three tested insecticides caused significant decrease in total protein concentration. These detected differences observed on values between enzymes tested of liver and kidney function by increase or decrease it is considered a sign and pronounced that treated animals affected by oral dose through 24 hr