Pharmacokinetics effects of some insecticides on white albino rats

ABSTRACT

The treatment of adults' female albino rats with Maximum Residue Limit [MRL] to tomato fruits of the three organophosphorus insecticides namely, primiphos-methyl, chloriphos-methyl and fenitrothion [1, 0.5 and 0.5 ppm] respectively on different periods [from 1. 6, 12, 24, 48, 96 hours and 7 days] to indicate and follow-up the effect of these insecticides on liver and kidney functions. A significant increasing activities of Aspartate Amino Transferase [AST] were found. No changes in Alanine Amino Transferase [ALT] and Alkaline phosphatase activities were observed in treated rats by the MRLs of the tested insecticides as compared with control. The data gathered showed that there were no significant changes in creatinine levels and urea concentrations of the treated rats at the different periods after dosing by the MRL of the tested insecticides. The data also clearly indicated an insignificant decrease in total protein levels, observed in rats treated by MRL of the tested insecticides after 1, 6, 12, 24, 48, 96 hrs and 7 days of treatment. Cholesterol level displayed slight or insignificant increasing in rats which were treated with the aforementioned insecticides. Generally treating rats by MRL of the prementioned insecticides resulted in a small [deleterious] effect on some biochemical parameters after 7 days of treatment. No effects have been detected at the first hours of the experiments