Synthesis and mass spectra of some aryl aldehyde thiosemicarbazones

ABSTRACT

The reaction of ethyl beta-aryl-alpha-cyanoacrylate [1] with thiosemicarbazide in the presence of potassium carbonate gave arylaldehydethiosemicarbazone [3]. Treatment of compound 3 with acetic anhydride, benzoyl chloride and ethyl chloroacetate yielded the corresponding 4-[substituted benzaldehyde-2, 4-diacetytl hiosemicarbazone] [4], 4 [substituted benzaldehyde -2, 4-dibenzoyl thiose micarbazones] [5], and 3-substituted-2-thioxo-imidazolidin-4-one [6]. The mass spectral fragmentation patterns of the compounds 3, 4, 5 and 6 are described