Assesment of soluble ICAM-1 and soluble E-selectin in juvenile idiopathic arthritis: clinical and laboratory correlation

ABSTRACT

To determine serum levels of soluble adhesion molecules [sICAM-1 and sE-selectin] in juvenile idiopathic arthritis patients. Also, to assess any changes in these levels during remission and exacerbation and to correlate them with clinical and laboratory variables. The serum and synovial levels of soluble intercellular adhesion molecule 1 [sICAM-1] and soluble E-selectin were determined using enzyme linked immunosorbent assay [Elisa] in 44 patients with JIA, 14 systemic [JIA-sys], 15 polyarticular [JIA-poly] and 15 oligoarticular [JIA-oligo], who had active disease or were in remission and 20 healthy controls. The erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] and complete blood count [CBC] were recorded. [sICAM-1] and [E-selectin] were significantly higher in both [JIA-sys] and [JIA-poly] than in [JIA-oligo] or healthy controls. There was a significant negative correlation [sICAM-1] and [s-E-selectin] and age. There was no correlation with some sensitive markers of inflammation [ESR] or [CRP]. [sE-selectin] correlated with white blood cells [WBC] and platelet count in the remission stage .There was a significant correlation between synovial adhesion molecules concentration and total synovial leukocytic count. Increased levels of soluble adhesion molecules in both [JIA-sys] and [JIA-pol] may be due to endothelial cell activation and its persistence in spite of clinical remission could be used as markers of aggressive disease