Synthesis and antibacterial activity of some new selenadiazole and thiadiazole containing amino acid moieties

ABSTRACT

The synthesis of 4-[substitute glycylaminophenyl-4-yl] 1,2,3- selenadiazoles [VI] and 4-[subtitute glycylaminophenyl-4-yl] 1,2,3- thiadiazoles [V] have been accomplished starting from 4-cloroacetylaminoacetophenone [I]. Compound/on reaction with different amines gives 4-glycylamiocetophenone derivatives [II], which on condensation with semicarbazide furnish the corresponding semicarbazones [III]. Oxidative cyclizatin of III either by selenium dioxide or thionyl chloride yields IV and V, respectively. Some of the compounds screened in vitro for their antibacterial and antifungal properties