Elevation and depletion induced by cholesterol derivatives in the level of total lipids on the major brain parts of albino rat

ABSTRACT

Changes in the level of total lipids on albino rat's brain [cerebrum, cerebellum and brain stem] were evaluated following the administration of four Cholesterol derivatives 3 beta-Acetoxy-5-bromo-6 beta hydroxy-5 alpha-Cholestane A [I], 3 beta-Acetoxy-6-dimethyl amino-Cholest-5-ene B [II], 3 beta Chloro-5-bromo-6 beta-nitro-5 alpha-Cholestane C [III] and 6 beta-Aminopyrimidino-Cholest-4en-3-one D [IV]. Experiments were carried out on four groups of six male albino rats weighing 200 +/- 20 gm. Control albino rats were administered saline solution intraperitoneally [ip.], while the other experimental groups were given 0.3 mg/kg body weight of steroidal solutions which was prepared in peanut oil