Synthesis of new derivatives of carnitine chloride

ABSTRACT

Five new carnitine chloride analogues were synthesized from lithio t- butyl acetate 2a and lithio t-butyl isopropionate 2b and the appropriate dimethylaminoketones 3a-c and 2-acetylpyridine. The condensation products 4a-d and 8 were converted to the required new acids 7a-d and 2 through few reaction steps. The selected molecular modifications don't affect markedly the main structural features of carnitine chloride. It is aimed that pharmacological testing of these new compounds may disclose the knowledge about the structure- activity relationship of carnitine chloride and its analogues