Association of gallstone disease risk with serum level of alkaline phosphatase

ABSTRACT

To see the relationship between personal history and blood chemistry of preoperative gallstone patients with gallstone disease. A Cross sectional study. Liaquat University Hospital Jamshoro for a period of three years. Gallstone patients admitted for the treatment during January 1999 to December 2001 were studied with the help of a predesigned proforma for recording the personal history and blood chemistry results of the individual patients. A total of 172 patients was studied. Majority [85.33%] of the gallstone patients was females. Females under 45 years age [65.38%] and females having more than three children [70.55%] were more prone to develop gallstones than the respective female group of over 45 years age [34.62%] and having upto three children [29.45%]. Past history of the gallstone patients revealed that 53.5%, 23.2%, and 9.3% of the cases had jaundice, diabetes mellitus and renal stones respectively. Blood chemistry of the patients showed that 18.2%, 2.8%, 3.44% and 4.1% had respectively hyperbilirubinemia, hyperuremia, hyperglycemia and hypoglycemia. Alkaline phosphatase and alanine aminotransferase levels in plasma and total leuckocyte count in blood were raised in 17%, 39.7% and 9% cases respectively. However, low plasma alkaline phosphatase levels were also found in 31.1% gallstone patients. The levels of plasma alkaline phosphatase were significantly high [p<0.01] in females than in males, and in females over 45 years age than under 45. Risk of gallstone disease in females is associated with serum alkaline phosphatase level