relationship between precence of antiphospholipid antibodies in pregnant womens' serum and preeclampsia

ABSTRACT

Antiphospholipid antibodies may be detected in normal pregnancies and may cause thrombosis, recurrent fetal loss, placental infarction and preeclampsia. In this study the possible differences in antiphospholipid antibody titer between healthy pregnant women and preeclampsic cases was examined. The antiphospholipid antibody titer in 50 healthy pregnant women with 50 preeclampsia cases without the history of thrombosis and autoimmune disease was compared. IgG and IgM anticardiolipin antibody was measured by immunoassay methods. Teclot kits were used for Lupus-like anticoagulant antibodies. Data was analyzed by Chi-square test, p<0/05 was considered significant. There was no association between antiphospholipid antibody titer in healthy and preecalamptic group. In normal pregnant women and preeclamptic cases there was 6% and 8% Lupus like anticoagulant antibody, 12% and 4% IgG anticardiolipin antibody and 26% and 30% IgM anticardiolipin antibodies respectively. Despite the evidence of prothrombotic state during preeclampsia, it is unlikely that antiphospholipid antibodies represent a risk factor for preeclamptic women as compared to healthy pregnant women