Preecamplsia is an important complication of pregnancy which can result in morbidity and mortality in mother, fetus and the neonate

ABSTRACT

This study was designed to determine the effect of garlic tablet [Gariet] on plasma lipids, and platelet aggregation levels and the efficacy of this treatment in the prevention of preeclampsia in four government hospitals in Tehran. in a randomized, single - blind, placebo - controlled study, 100 primigravidas with positive roll-over test were treated with daily doses of 800 mg/day Gariet [n=50] or 800 mg/day placebo [n=50] during the third trimester of pregnancy. In this study serum total cholesterol, LDL- an HDL cholesterol, triglyceride, and platelet aggregation were measured before and after the treatment. Blood pressure, weight, and edema were also examined during the entire study period. in the case group, there was no significant difference in the means of total cholesterol, HDL, LDL, and triglyceride before and after the experiment. Furthermore, the inhibition of platelet aggregation did not show any significant difference before and after the treatment. There were not significant differences in the means of HDL, LDL, triglyceride, inhibition of platelet aggregation, the means of systolic and diastolic blood pressure and the mean arterial blood pressure [MAR], between the two groups, but there was a significant difference in the means of total cholesterol [p=0.038] and hypertension alone [p=0.043]. the administration of 800 mg/day of garlet during the third trimester of pregnancy was effective in reducing the occurrence of hypertention alone, but it was no effective in preventing preeclampsia