Studies on twenty-two thalassemic patients from Fars province [Southern Iran]

ABSTRACT

In vitro synthesis of hemoglobin by reticulocytes from twenty-two patients [fourteen males, eight females] severely affected with thalassemia was carried out. These patients were randomly selected from Pars Province in Southern Iran. [14]C-labelled leucine was used and separation of the alpha, beta and gamma chains by chromatography on carboxymethyl cellulose in 8M urea is reported, The data show that all patients had beta-thalassemia with various degrees of severity, and that no alpha-thalassemia was encountered