Hydroxy ethyl starch versus Human albumin in ovarian hyperstimulation syndrome

ABSTRACT

To compare between Hydroxyethyl starch and Human albumin efficacy in preventing moderate to severe ovarian hyperstimualion in assisted reproduction treatment cycles and as well, to define possible adverse effect of Hydroxyethyl Starch on the cycle outcome compared to human albumin. Randomized controlled study Setting Galaa assisted Reproduction Unit of Al-Galaa Teaching Maternity Hospital. Thirty-one women undergoing IVF/ICSI treatment cycles who were considered at risk of ovarian hyperstimualion syndrome. Interventions The 31 women was randomly divided into two groups; Group A consisted of 11 ladies, who received Hydroxyethyl starch 6%[500ml] and Group B [20 women] to whom human albumin 20% [100 ml] was administered. Both drugs were administered intravenously at the time of egg collection. The incidence of moderate-severe ovarian hyperstimualion syndrome, and pregnancy rate were compared in both groups. Incidence of moderate-severe ovarian hyperstimualion syndrome was 9.1% in group A and 15% in group B. Although pregnancy rate in group A was 36.4% and 20% in group B, P-value was 0.4, which is statistically insignificant. Hydroxyethyl starch is a cheap and safe alternative to human albumin in the prevention of ovarian hyperstimualion syndrome, as both reduce the overall incidence of moderate to severe ovarian hyperstimualion syndrome, without adversely affecting the pregnancy rate