Role of tolterodine in management of over active bladder [OAB] in different age groups

ABSTRACT

To assess the efficacy of tolterodine in management ofnon neurogenic overactive bladder in all ages and both sexes, also to evaluate the expected side effects and compliance of the patients with such anticholinergic drug. In prospective study one hundred patients 43 females, 50 males, and 7 children entered in the study all came complaining of symptoms of OAB to the urology clinic, all had a base line pressure flow studies except the children. After the initial evaluation, all patients were treated by tolterodine [Detrusitol] 2mg twice daily and in some resistant cases it may increase into three times daily, basically for three months period extends to 6 months in partially responded patients and repeated for those with relapsed after being good responders. Of the 100 patients, complete response occurred in 63 [63%], partial response in 27 [27%], and no response in 10 [10%], with the female population showed the majority of responders, followed by non bladder outflow obstruction [B.O.O] male patients, also in pediatric patients it shows considerable response