effects of fumitory parviflora extract on gastric acid and pepsin secretion in rat

ABSTRACT

Fumitory-parviflora is a plant from papaveracea family that is used for treatment of some GI tract diseases. So far there hasn't been a study performed on the effects of extract of fumitory-parviflora on gastric acid and pepsin secretion. This study is designed to define the effect of the extract of fumitory-parviflora on basal and pentagastrin induced gastric acid and pepsin secretion in rat. Both of the groups were anesthetized with sodium thiopental. The test group received 600 mg/kg, IP fumitory-parviflora extract. After tracheostomy and laparotomy gastric effluents were collected by wash out technique in 15 minute intervals and total titrable acid was measured by acid titrator. The pepsin content was measured by Anson method. Pentagastrin [25 micro g/kg, IP] was used to stimulate the secretion of acid and pepsin The results of this experiment showed no significant differences between basal acid and pepsin secretion in group that received extracts of fumitory-parviflora in comparison to the control group. According to the results, there was a significant difference between amount of basal and stimulated acid secretion in the control group but not in the test group. There was significant increase of pepsin secretion after stimulation in comparison to basal state in both groups. Also this difference in the control group is significantly more than the test group. Fumitory-parviflora prohibts the stimulatory effect of pentagastrin on acid and pepsin secretion