Cod liver oil and liquid paraffin oil induced exogenous lipoid pneumonia in albino rats

ABSTRACT

This work was carried out on 30 adult albino rats of both sexes, divided into 3 numerically equal groups, 10 animals per each. The study aimed to highlighten the pathological features of cod liver oil and liquid paraffin induced exogenous lipoid pneumonia and increase the awareness of pediatricians and physicians about it to be kept in consideration in the differential diagnosis of various lung conditions, especially if there is history of chronic constipation and chronic intake of oil based laxatives. Cod liver oil group [Group II] received 0.5 ml/kg/day oral cod liver oil and liquid paraffin group [Group III] received 0.66 ml/kg/day oral liquid paraffin in a single daily dose for 12 successive weeks. Pathological specimens were taken from both lungs and examined, by hematoxylin and eosin, wilder silver, orcein and Prussian blue stains. Results revealed extensive pulmonary parenchymal damage and disturbed lung architecture in the form of consolidation, granulomatous formation, fibrosis, lymphocytic and foam cells infiltration. Group II showed more extensive and diffuse consolidation while Group III showed more extensive fibrosis and more abundant granulomatous masses