Synthesis and hypoglycemic activity of some new 4[3H]- quinazolinone analogues

ABSTRACT

The synthesis and biological evaluation of many 3-[4-[[[[cyckohexylamino] carbonyl]amino]sulfonyl]phenyl-4[3H]-quainzolinones [IVa-t] as oral hypoglycemics are described. Derivates [IVf], [IVg], [IVh], [IVj], [IVk], [IVm], [IVq] and [IVr] showed appreciable glucose lowering effects in alloxanized diabetic rats at a dose of 5 mg/kg. They decreased the blood glucose level by 40.7, 36.4, 37.2, 35.4, 43.7, 38.8, 35.3, 42.9 and 45.9 respectively. The hypoglycemic action of the synthesized compounds is comparable to, and in few cases is higher than that exhibited by the well known antidiabetic drug "glyburide" which showed 35.1 percent decrease of the blood glucose level