[Do biologic parameters [prothrombin time platelets], allow to assess the degree of fibrosis in liver diseases?]

ABSTRACT

The goal of our study is to assess the performance of a score combining 3 serological parameters [PT, platelets and transminases] in predictive hepatic fibrosis. The study involved 54 patients, 29 of which resulted in distributing them according to the score of Metavir into 2 groups Group A with mild fibrosis [F1,F2] and group B with severe fibrosis [F3,F4]. PT, platelets and transminase values in serum were assessed for all patients. The total score of the 3 biological parameters combined, was significantly more enlabled in the severe fibrosis group than in the mild fibrosis group [P=0,01] but it was not of much importance in 30% of cases as it did not allow to classify the patients with certainty in group A or in group B. This score does not seem to grant exemption from needle liver biopsy, but it can be improved by the association of other direct markers of fibrosis