Intrauterine administered levonorgestrel releasing system [Mirena] for symptomatic endometriosis treatment

ABSTRACT

To investigate the effectiveness, continuation rates and side effects of levonogestrel releasisng intrauterine system [Mirena], in treating symptomatic stage I or II endometriosis, [according to revised American fertility society classification [rAFS]. Prospective therapeutic, trial analysing changes in pain symptomes in response to the use of the intrauterine levonorgestrel releasing sys tem [IUS] over 12 months of continuous use. Thirty-five symptomatic patients with either stage I or II endometrosis, diagnosed laparoscopically. An intrauterine leronogestrel-releasing system [IUS] [Mirena coil] was inserted and potentially maintained for up to 12 months following endometriosis diagnosis. Severity of dysmemorrhea, normenstrual pelvic pain [chronic pelvic pain] and deep dyspareunias were assessted before insertion of IUS and throughout the study period at 3 months, 6 months, and 12 months follow up visits. Dysamenorrhea, nonmenstrual pelvic pain, and deep dvspareunia markedly improved and their severity were significantly reduced by intrauterine levonorgestrel releasing system, IUS [Mirena]