Some variables affecting microencapsulation of d-alpha tocopherol succinate

ABSTRACT

d-alpha tocopherol succinate, [Vit.E] is one of the most important vitamin, that is incorporated in food and nourishment due to its high biological activity against free radical formation inside cells. This study was illustrated in the followings Microcapsules of d alpha tocopherol were prepared from different core wall ratios 11, 12 and 13 by solid dispersion method using ethyl cellulose [Ethoel] polymer. The powdered microcapsules with 11 corewall ratio is formulated as tablets with good appearance and hardness. The drug release was found to be increased as a function of increasing, core wall ratio, stirring speed and pH medium. The profile of cumulative different pH medium release of the drug gives rise an indication of prolonged release dosage form. [during 6hrs. of dissolution]