Goserline versus danazol in the treatment of endometriosis

ABSTRACT

The objective of this study was to achieve symptoms relief of endometriosis with a drug having better efficacy and least side effects. Experimental. Lady Willingdon Hospital, Lahore from March, 2003 to Feb. 2005. The trial was conducted on two groups; one group [n = 20] received goserline and other group [n=20] received danazol for 6 months. Patients were followed for relief of symptoms including dysmenorrhoea, dyspareunia, lower abdominal pain and menstrual irregularity and appearance of side effects. The results depicted that in Danazol group 50% pain relief was found in 5 patients [25%] while in goserline group in 4 patients [20%]. 75% pain relief was seen in 7 patients [35%] in danazol group and 8 patients [40%] in goserline group. 100% of improvement in pain found in equal number of patient that is 8[40%] in both groups. Both drugs were effective in pain relief [P >0.05], Goserline had less side effects as compared to Danazol [P<0.05]. Goserline and Danazol are equally effective in symptomatic relief of endometriosis while side effects favoured use of GnRH agonist