Effects of prolonged poisoning by cobra venom on blood coagulation, platelets and fibrinolysis
Biomedica. 2006; 22 ([Jul-Dec]): 143-146
em Inglês
| IMEMR
| ID: emr-76330
ABSTRACT
The effects of Cobra Venom [CV] on blood coagulation, platelets and fibrinolytic system were studied in rabbits after injecting repeated doses of 0.05 MLD of the Venom. Thrombocytopenia was the earliest change to appear. It was followed by rise in serum fibrinogen degradation products and prolongation of prothrombin time, [PT] activated partial thromboplastin time [APTT] and thrombin time [TT] indicating a progressive consumption coagulapathy and activation of fibrinolysis. Red blood cell morphology was unchanged during first three weeks; whereas fragmentation appeared after fourth week and it increased in severity with further envenomations i.e., when chronic disseminated intravascular clotting was established
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Venenos de Serpentes
/
Transtornos da Coagulação Sanguínea
/
Testes de Coagulação Sanguínea
/
Plaquetas
/
Coagulação Intravascular Disseminada
/
Fibrinólise
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedica
Ano de publicação:
2006
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