Evaluation of serumic beta-2 microglobulin in HBsAg+ HBV DNA PCR+ and HBsAg+ HBV DNA PCR- subjects: as HBV replication marker
Blood. 2006; 2 (6): 253-258
em Persa
| IMEMR
| ID: emr-76336
ABSTRACT
Beta-2 microglobulin [beta2MG] is the light chain of Histocompatibility-Class I human antigen and its normal range is <3mg/ml. beta2MG level in sera of hepatitis B patients increases. In Hepatitis infection the presentation of the viral antigen on the hepatocyte in the presence of Class I HLA antigen plays a major role in the elimination of the virus. In this descriptive study, s beta2MG, HBsAg [by ELISA], and HBV DNA [by PCR] were evaluated in sera of49 patients with hepatitis B and 35 subjects in control group. Our results showed HbsAg was positive in all patients. 29 of patients were HBV-DNA-PCR positive and 20 HBV-DNA-PCR negative.beta2MG in all subjects in control group was in normal range and in 34.7% of patients above normal limit. beta2MG in HBV-DNA-PCR positive patients was higher than HBV DNA PCR negative patients. Such differences were significant [p <0.05]. It seems S beta2MG is a good marker for HBV replication and its absence may exclude HBV replication. The role of beta2MG in monitoring response to therapy needs to be further evaluated
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ensaio de Imunoadsorção Enzimática
/
Biomarcadores
/
Reação em Cadeia da Polimerase
/
Antígenos de Superfície da Hepatite B
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Persa
Revista:
Blood
Ano de publicação:
2006
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