Comparison of the effect of metoclopramide and droperidol associated with dexamethasone on nausea and vomiting after operation

ABSTRACT

One of the most common complications after general anesthesia is nausea and vomiting that can cause spasm, hypoxia and pulmonary aspiration. Metoclopramide and dropridol are two common drugs to prevent nausea and vomiting after operation. On the other hand adding dexamethasone to these drugs is effective in decreasing nausea and vomiting. The purpose of this study was to compare the effect of metoclopramide and dropridol on prevention of nausea and vomiting after operation. In this study, 160 patients were randomly divided into two groups of 80 patients. Patients in both groups were equally administered with premedication and induction of anesthesia according to their weight. The first group was injected with metoclopramide associated with dexamethasone and the second group was injected with dropridol associated with dexamethasone. After removing tracheal tube, nausea and vomiting in both groups were assessed for two hours and then data was compared to each other. Postoperative nausea and vomiting in first group was 24% and in second one was 8%. Nausea and vomiting in females was more than males [p=0.049]. According to the results, dropridol associated with dexamethasone can cause decreasing of nausea and vomiting in patients after general anesthesia