Effect of Allium sativum L. aqueous extract on contraction power of isolated atrium from rats following administration of adrenaline

ABSTRACT

Synthetic drugs, although very effective, have their own side effects. Recently, herbal plants have received more attention to avoid the unpleasant effects of synthetic agents. To investigate the effects of garlic aqueous extract on contraction power of isolated atrium from male rats following administration of adrenalin. Male rats [Spirague Dawley, Albino, 200-250 gr] were divided into 7 groups as follows Control, adrenalin, garlic extract [10 mg/kg, 20 mg/kg, and 40mg/kg], Propranolol and Propranolol plus garlic extract at a single concentration of 40 mg/kg. Later the contraction power was recorded using a physiograph set. Garlic extract at all three concentrations used in our study caused a reduction of atrial contraction power in adrenalin group. When the degree of contraction power reduction was compared between garlic extract [40mg/kg] and garlic extract plus Propranolol groups, no statistically significant difference found. Atrial contraction power decreased in presence of garlic aqueous extract and the degree of reduction was significant in both low and high doses, statistically