Evaluation of the potential protective effect of captopril against doxorubicininduced cardiotoxicity in rats

The purpose of this study was to investigate the possible protective effect of Cap, an angiotensin-converting enzyme inhibitor with an antioxidant property, against DOXinduced cardiotoxicity. Results of the present study showed that DOX decreased significantly plasma activities of CK, CK-MB and LDH, while it produced a significant increase in serum NO level, cardiac MDA level and CAT activity. Significant reductions in cardiac GSH level and GPx activity were also produced. Administration of Cap one hour before DOX treatment attenuated the reduction in CK-MB activity. The combined treated group showed significant decrease in cardiac MDA level. Also, DOX concentration was markedly decreased in both serum and cardiac tissue. Data of the present study showed that Cap had limited protective effect on cardiotoxicity produced by DOX treatment. The mechanism by which Cap exerts its protective effect may involve inhibition of lipid peroxidation