Allergic reactions in patients suffering from asthma induced by house dust mites which treatment by juvenile hormone

ABSTRACT

The effect of Juvenile hormone analogue, Admiral "pyriproxyfen", which acts as a protein de-naturing agent, on the protein patterns of D. farinae was studied on allergic reactions in patients with HDM asthma, and in mice injected twice [within 10 days] with mite crude extracts. Total protein concentrations and protein patterns were different in normal and admiral-treated mites. This may result in reducing the allergenic of treated mites. Histamine release, total immunoglobulin E [IgE], specific immunoglobulin E [S-IgE], eosinophil cationic protein [ECP], and absolute eosinophil count [AEC] were determined for moderate and severe HDM asthmatics compared to check cases. These parameters had higher levels in asthmatic patients than in normal [check] individuals. Injection of mice with normal adult extracts of D. farinae resulted in significantly higher levels of histamine, S-IgE and ECP than in the check animals. Skin reactions were observed in all of the mice injected with normal or treated D. farinae extracts