[Correlation between serum uric acid level in children with congenital heart disease and severe pulmonary hypertention]

ABSTRACT

This study evaluated correlation between serum uric acid level with pulmonary hypertension and progress of pulmonary vascular disease in children with Congenital Heart Disease [CHD] and Eisenmenger syndrome. This case-control study was performed on 75 patients with congenital heart disease, from Mar 2001 to Apr 2004 that had referred to pediatric cardiology ward in Ali-Asghar hospital, Zahedan and then cardiac catheterization performed at Khatam Hospital. Among 75 patients, 25 cases suffered from Eisenmenger syndrome [group 1], 25 cases had pulmonary hypertension [group 2] and 25 cases were in control with normal pulmonary artery pressure [group 3]. Then collected data were analyzed with SPSS and Chi-square, Mann-Whitney, Kruskal-Wallis and correlation tests and then results of three groups were compared to one another. Mean age in Eisenmenger syndrome [group 1] was 2.75 +/- 2.23 years, in pulmonary hypertension [group 2] 3.52 +/- 3.76 and in control [group 3] 4.01 +/- 2.34 [P>0.05]. There was no significant statistical difference between three groups regarding age and sex [P>0.05]. The mean pulmonary artery pressure was 71.65 +/- 9.26 in group 1, 39.22 +/- 10.09 in group 2 and 13.65 +/- 1.69 mmHg in group 3 [P<0.001]. The mean QP/QS ratio was 1.2 +/- 0.29 in group 1, 1.89 +/- 0.31 in group 2 and 1 +/- 0 in group 3 [P<0.001]. The mean RV pressure was 92.2 +/- 12.72 mmHg in group 1, 60.4 +/- 16.7 in group 2 and 25.44 +/- 3.29 in group 3 [P<0.001]. The mean pulmonary vascular resistance was 0.952 +/- 0.1 in group 1, 0.33 +/- 0.12 in group 2, and 0.13 +/- 0.01 in group 3 [P<0.001] there was a correlation between serum uric acid level and pulmonary vascular resistance in group 1 [r=0.425, P<0.034]. The mean serum uric acid level was 6.83 +/- 2.07 mg/dl, 4.01 +/- 1.14, 4.45 +/- 0.75 in the three groups respectively [P<0.05]. Also this study showed that there is no statistical significant relationship between mortality rate and serum uric acid in group 1. In this study, a significant correlation between increased serum uric acid level and increased pulmonary vascular resistance in patients -with Eisenmenger syndrome -was found and there was no a significant correlation between serum uric acid level and pulmonary vascular resistance in other groups. So serum uric acid could be used for prediction of severity and progress of Eisenmenger syndrome in children with congenital heart disease [CHD]