Oxidative stress and antioxidant vitamins in obese children
JPC-Journal of Pediatric Club [The]. 2006; 6 (2): 99-102
em Inglês
| IMEMR
| ID: emr-78458
ABSTRACT
Oxidant-antioxidant status was investigated in a group of obese children in comparison with healthy subjects by determination of malondialdehyde [MDA], tocopherol, and ascorbic acid. Thirty five obese children [25 male and 10 female] mean age [9 +/- 4.4year] with BMI > 2SD of the mean for age and sex [BMI = 31.5 +/- 6.6]. A group of 30 healthy, age and sex matched children were used as a control group. Blood samples were collected from every subject and control after an overnight fast of which 2ml blood collected on heparin for plasma ascorbic acid [vitamin C] and 4ml blood collected into plain tube for serum tocopherol and malondialdehyde [MDA]. MDA was significantly higher in obese children compared to control [P=0.0001]. This was associated with significantly lower plasma vitamin E and vitamin C in obese children compared to control [P= 0.0001]. BMI was positively correlated with age and MDA and showed negative correlation with vitamin E and C. Severely obese children present a highly altered oxidant antioxidant status, which is alarming for the increased risk of complication so early intervention has been recommended by giving antioxidant, diet-control and exercise
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ácido Ascórbico
/
Exercício Físico
/
Índice de Massa Corporal
/
Criança
/
Estresse Oxidativo
/
Tocoferóis
/
Malondialdeído
/
Antioxidantes
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Pediatr. Club
Ano de publicação:
2006
Similares
MEDLINE
...
LILACS
LIS