New onset diabetes mellitus after renal transplantation: impact of immunosuppresssive and antihypertensive therapy
Medical Journal of Cairo University [The]. 2006; 74 (Supp. 2): 109-113
em Inglês
| IMEMR
| ID: emr-79460
ABSTRACT
The purpose of the present study was to assess the influence of immunosuppresssive and antihypertensive therapy in the diabetic state after renal transplantation especially impaired fasting glucose [IGF], and impaired glucose tolerance [IGT]. A total of 67 consecutive renal transplant recipients without previously known diabetes underwent a 75gm oral glucose tolerance test [OGTT] 3 months after renal transplantation. BMI, daily prednisolone dose, creatinine clearance, hypertension, number of antihypertensive agents and the use of diuretics or 3 blockers were POSITIVELY associated with, impaired glucose tolerance [IGT], namely impaired fasting glucose [IGF], and abnormal glucose tolerance [ACT] [p<0.05]. After multiple regression analysis, BMI [p<0.001], daily prednisolone dose [p<0.001], cytomegalovirus infection [p<0.03], and triglycerides [p<0.034], were shown to be independent predictors of posttransplant ACT. Increasing daily prednisolone dose is an independent predictor of impaired fasting glucose after renal transplantation. Hypertension and the use of diuretics and beta blockers may also deteriorate glucose tolerance [CT] in this group of patients
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Índice de Massa Corporal
/
Prevalência
/
Intolerância à Glucose
/
Diabetes Mellitus
/
Teste de Tolerância a Glucose
/
Imunossupressores
/
Anti-Hipertensivos
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Cairo Univ.
Ano de publicação:
2006
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