Effect of pancreatectomy on blood sugar and lipid levels in various tissues of a lizard [Uromastix Hardwickii]

ABSTRACT

1. The effect of pancreatectomy on blood sugar and lipid levels was studied in a lizard, Uromastix hardwickii. 2. The blood sugar decreased gradually till 72 hours after pancreatectomy. 3. Glyceride level of plasma and adipose tissue was decreased in depancreatized animals, while liver glyceride level was slightly increased. 4. The plasma and adipose tissue cholesterol was elevated in depancreatized animals while liver cholesterol level was not changed. 5. Elevated level of plasma phospholipid was maintained 24 hours after pancreatectomy. The liver phospholipid was first increased, and returned to normal level after 24 hours. 6. The major fatty acids of adipose tissue were palmitic, stearic, oleic and linoleic. 7. The stearic acid was reduced during 16-48 hours after pancreatectomy with the concomitant increase in oleic acid. 8. The long chain fatty acids were eliminated after 24 hrs. of pancreatectomy, while the short chain fatty acids were accumulated