Determination of possible interactions of citalopram hydrobromide with different excipients

ABSTRACT

Differential scanning calorimetry [DSC] and Infrared spectroscopy were used as a screening techniques for assessing the possible interactions of citalopram hydrobromide [CTH] with some currently used pharmaceutical excipients in formulation of rapidly dispersible tablets and capsules. On the basis of the DSC,NMR, UV and IR results CTH was found to be compatible with maize starch,talc, fill starch 1500,anhydrous lactose,magnesium sulphate, starch sodium glycolate,polyvinylpyrrolidoneK29/32, magnesium strearate, polyethylene glycol 4000, Avicel PH101, pharmaburst and Avicel PH101. DSC results showed some minor interactions with propylene glycol, sorbitol, Avicel PH102, soluble starch.lactose monohydrate and mannitol