Decreased ability of human plasma to inhibit lipid peroxidation in uremia

ABSTRACT

Blood samples from normal healthy volunteers and uremic patients were obtained and plasma were prepared. The effects of these plasma samples on lipid peroxidation [LP] in rabbit homogenate were determined. Both plasma samples inhibited LP activity in our experiments. The percent inhibition of LP produced by normal plasma, concentration 1 and 10%, v/v, was 21.78 +/- 4.15 and 75.5 +/- 2.39 [Mean +/- S.E.M. n=20] respectively. The corresponding values of LP inhibition obtained using the uremic plasmas, concentrations 1 and 10% v/v, were 6.85 +/- 7.04 and 57.12 +/- 13.71 respectively. These data show that there was a significant reduction in LP inhibitory activity in plasma of uremic patients. This suggests that there may be an increased production of associative LP products in uremic patients. Since LP products profoundly affect blood clotting it can be inferred that aberrant levels of LP inhibitor in uremic plasma could contribute to increased bleeding in uremia