Formulation and evaluation of meloxicam gels for topical administration
SPJ-Saudi Pharmaceutical Journal. 2006; 14 (3-4): 155-162
em Inglês
| IMEMR
| ID: emr-81161
ABSTRACT
For topical administration ofmeloxicam [ME], microemulsion gels and lipogels containing either ethyl oleate or oleic acid as an oil phase were prepared. In addition, Hydrogel and hydroalcoholic gels containing carbopol 940 as a gelling agent were also prepared. In-vitro drug release through cellophane membrane and permeation through the excised rabbit skin in Sorensen's phosphate buffer [pH 7.4] containing 1% w/v sodium lauryl sulphate were performed. The influence of initial drug concentration [0.5, 0.65, 1% w/w] was studied. The permeation properties of ME from ethyl oleate microemulsion which is the best formula achieved was studied in comparison to the commercially available piroxicam gel. Moreover, the anti-inflammatory activity of ME after oral and topical administration in rats was studied and compared to that of piroxicam gel. The results of an in-vitro drug release and its percutaneous permeation revealed that the ethyloleate microemulsion gel showed the highest results. Meloxicam gel [ethyl oleate microemulsion gel 1%] showed good protection against inflammation as compared to Feldene gel in rats
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Química Farmacêutica
/
Anti-Inflamatórios não Esteroides
/
Administração Tópica
/
Avaliação de Medicamentos
Idioma:
Inglês
Revista:
Saudi Pharm. J.
Ano de publicação:
2006
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